Endocrine Abstracts

Introduction: Pancreatic endocrine tumors are rare lesions, with an incidence of 4 cases per 1 million pts-yr. Of these lesions,insulinomas are the most common. The nonspecific symptoms and small sizes of these tumors led to difficulties of diagnosis and localization.Case report: A 60 year female pts, had history of episodic and repetitive symptoms of strong headaches for the last 5 years; which were relieved with eating or taking glucose water orally. S...

Latent autoimmune diabetes of adulthood (LADA) is the most common form of autoimmune Diabetes diagnosed in Adults. Approximately 5–12%of cases in Europeans with apparent type2Diabetes are in facts misdiagnosed LADA. This is a heterogeneous condition that presents with clinical and laboratory manifestations common to type1diabetes and type2 diabetes. Its main feature is the presence of diabetes-associated autoantibodies (mostly autoantibody against glutamicaciddecarboxylas...

Introduction: A thyroid nodule discovered in a patient with Graves’ disease (GD) should be evaluated and managed according to guidelines. A subcentimetre incidental thyroid cancer founded in a patients with GD, without high-risk history, without suspicious sonographic (US) features has not been reported yet.Clinical case: A 40-year-old female patient, presented to our hospital with symptoms of thyrotoxicosis. On physical examination heart rate was 1...

Introduction: Metformin-associated lactic acidosis (MALA) is defined as a high anion gap metabolic acidosis with high circulating lactate levels and without hypoperfusion. It is associated with a mortality rate up to 50%.The reported frequency is 0.01–0.05/1000 patient-years, mostly in patients with predisposing factors (which affect its clearance or energy metabolism) such as altered renal function, congestive heart, hepatic and respiratory failure, concomitant medicatio...

Introduction: Although psychiatric manifestations in the form of delirium, confusional states, and psychosis have been commonly reported in relation to hypoglycemia, association of hyperglycemia with psychiatric manifestations has been less commonly reported. Acute hyperglycemia is known to alter mood state and impairs cognitive performance in patients with diabetes mellitus. However, association of acute psychosis (in the absence of cognitive disturbances) with hyperglycemia ...

Introduction: Hyponatremia (defined as a serum sodium level <135 mmol/l), is seen in in 15–30% in hospital setting, especially in intensive care units. Certain drugs (e.g.Thiazides diuretics) used in everyday clinical practice, may induce hyponatremia, more frequently in elder women.Case report: A 76-year-old woman presented at emergency unit with complaints: physical weakness, nausea, vomiting, extreme fatigue and abdominal pain. She was under ...

Introduction: Adrenomyeloneuropathy (AMN) is a form of X-linked adrenoleukodystrophy (X-ALD) a rare inherited disorder (estimated prevalence 1:20 000 to 1:50 000) characterized by the accumulation of very long chain fatty acids (VLCFA) and affects mainly the nervous system white matter and the adrenal cortex and nearly 100% penetrance in males. Widely varying phenotypes and prognoses often co-occur in a single kindred.Methods: We report a case diagnosed ...